Synthesis of tryptophans by alkylation of chiral glycine enolate equivalents with quaternary gramines
2015
Reinfelds, Matiss | Kalinins, Konstantins | Katkevica, Dace | Zemribo, Ronalds | Katkevics, Martins
Quaternary gramines were found to be a suitable source of the 3-methylindole fragment for diastereoselective alkylation. The best yields and stereoselectivity were obtained for the alkylation of a chiral William’s morpholinone enolate. Based on this transformation, a general method for the synthesis of enantiopure, indole ring substituted tryptophan derivatives was developed with good overall yields.
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书目信息
Tetrahedron letters
卷
56
期
43
页码
5882
- 5885
ISSN
0040-4039
出版者
Elsevier Ltd
其它主题
Enantiomers; Diastereoselectivity; Alkylation; Gramine; Diastereoselective alkylation; Williams’ morpholinone
语言
英语
类型
Text; Journal Article
2024-02-29
MODS