Vergleichende Messungen von Magenentleerung, Blutglukose und orozökaler Transitzeit nach einer konventionellen Morgenmahlzeit und einem Kollath-Frühstück
1998
Leitzmann, P. | Heine, W. | Wutzke, K.D. | von Bismarck, P. | Dorlöchter, L. | Miera, O. | Bührlen, M. | Cornelißen, B.W. | Höcker, C.
Blood glucose kinetics and intestinal transit times were investigated in 12 adult volunteers aged 28 to 52 years after ingestion of a conventional morning meal made up of white flour rolls, butter, marmelade, and coffee with sugar as compared with an isocaloric Kollath-breakfast consisting of whole wheat flakes as a basis.For estimation of gastric emptying time the sodium-[¹³C]acetate breath test technique was used. Oro-coecal transit time and gastric emptying were determined by simultaneous administration of lactose-[¹³C]ureide and consecutive drawings of breath samples in intervals of 15, 30, and 60 min through 12 h. The ¹³CO₂-excess of the breath test samples was measured by continuous flow isotope ratio mass spectrometry.The postprandial rise in blood glucose following the ingestion of the Kollath-breakfast was lower as compared with the conventional morning meal, showing significant differences between the 90 min values and the area below the blood glucose curve.The half time of gastric emptying was not different between the two breakfast versions (1.7 vs. 1.6 h).The oro-coecal transit time averaged out at 4.2 h after the Kollath-breakfast and 5.3 h following the conventional morning meal. Likewise, there were no significant differences in the coecal retention time nor in the cumulative percentage of ¹³CO₂-exhalation between the two breakfast versions. Concerning the blood glucose kinetics the differences in the nutritional physiology between the breakfast based on whole wheat flakes and the conventional breakfast as claimed by Kollath were only detectable in outlines in our study. Gastric emptying time showed no differences between the two breakfast versions.
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