Isolation of 4-chlorocinnamic acid from Streptomyces griseocarneus R132, and its inhibition activity against sweet pepper postharvest anthracnose
2022
de Siqueira, Kátia Aparecida | Liotti, Rhavena Graziela | Januário, Ana Helena | Vieira, Lucas Campos Curcino | de Araújo Boleti, Ana Paula | dos Santos, Edson Lucas | Soares, Marcos Antônio
Streptomyces griseocarneus R132 is an actinobacterium capable of controlling fungi in sweet peppers. The crude S. griseocarneus R132 methanol extract was fractionated in a polystyrene-divinylbenzene column eluted with 20–100% acetone gradient. Compound 1 isolated from the 60% fraction was identified as 4-chlorocinnamic acid. This fraction and 4-chlorocinnamic acid inhibited Colletotrichum gloeosporioides growth by 28% and 65%, respectively, and reduced the diameter of lesions caused by the phytopathogen in Capsicum annuum L. fruits by 33.19% and 31.92%, respectively. The isolated 4-chlorocinnamic acid was not toxic to MRC-5 fibroblasts.
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