Expedited synthesis of mannose-6-phosphate containing oligosaccharides

Sletten, Eric T.; Danglad-Flores, José; Leichnitz, Sabrina; Abragam Joseph, A.; Seeberger, Peter H.

Expedited synthesis of mannose-6-phosphate containing oligosaccharides

2022

Sletten, Eric T. | Danglad-Flores, José | Leichnitz, Sabrina | Abragam Joseph, A. | Seeberger, Peter H.

Currently, the reaction toolbox for the functionalization of glycans assembled on solid-phase is quite limited. Automated (1 h) and manual (overnight) phosphorylation protocols that enable the solid-phase synthesis of oligosaccharides containing up to two mannose-6-phosphates are presented. Automated glycan assembly expedited access to substrates and facilitated the screening of experimental conditions.

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