Anti-angiogenic Activity of Tocotrienol
2003
INOKUCHI, Hitoshi | HIROKANE, Hisako | TSUZUKI, Tsuyoshi | Nakagawa, K. (Kiyotaka) | IGARASHI, Miki | MIYAZAWA, Teruo
The anti-angiogenic property of vitamin E compounds, with particular emphasis on tocotrienol, has been investigated in vitro. Tocotrienol, but not tocopherol, inhibited both the proliferation and tube formation of bovine aortic endothelial cells, with δ-tocotrienol appearing the highest activity. Also, δ-tocotrienol reduced the vascular endothelial growth factor-stimulated tube formation by human umbilical vein endothelial cells. Our findings suggest that tocotrienol has potential use as a therapeutic dietary supplement for minimizing tumor angiogenesis.
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