Isolation of cytochrome P450 3A (CYP3A) inhibitors from Hyuganatsu, Citrus tamurana Hort
2006
Hosoi, Shinzo | Shimizu, Eri | Usami, Noriyuki | Yamamoto, Ikuo | Arimori, Kazuhiko | Okumura, Manabu | Hidaka, Muneaki | Yamada, Mitsuko | Sakushima, Akiyo
The present study was conducted to identify cytochrome P450 3A (CYP3A) inhibitory components of Hyuganatsu, Citrus tamurana Hort., by investigating the effects on midazolam 1′-hydroxylase activity of human liver microsomes. As a consequence, limonin and nomilin were identified as CYP3A inhibitors from the endocarp of Hyuganatsu.
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书目信息
Natural medicines
卷
60
期
3
页码
240-242
- 242
ISSN
1340-3443
出版者
Herpetologists' League
其它主题
Liver microsomes; Cytochrome p-450
语言
英语
类型
Journal Article; Text
2024-02-29
MODS