Withaminimas A—F, six withanolides with potential anti-inflammatory activity from Physalis minima
2019
WEI, Shan-Shan | GAO, Cai-Yun | LI, Rui-Jun | KONG, Ling-Yi | Luo, Jun
Withaminimas A—F (1—6), six new withaphysalin-type withanolides were isolated from the aerial parts of Physalis minima L.. The structures of these compounds were elucidated through a variety of spectroscopic techniques including HR-MS, NMR, and ECD. Compound 1 belongs to rare 18-norwithanolides, and 2—3 were 13/14-secowithanolides. According to the traditional usage of P. minima, inhibitory effects on nitric oxide (NO) production in lipopolysaccaride-activated RAW264.7 macrophages were evaluated, and compounds 1—4 exhibited significant inhibitory effects with IC50 values among 3.91—18.46 μmol·L−1.
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