Organocatalytic Enantioselective Formal (4 + 2)-Cycloadditions of Phosphine-Containing Dipoles with Isocyanates
2022
Chen, Xuling | Wang, Tao | Lu, Zhongyue | Li, Pengfei
Phosphine-catalyzed enantioselective formal (4 + 2)-cycloadditions of 2-(4H-benzo[d][1,3]oxazin-4-yl)acrylates with isocyanates have been developed for the first time. The initial SN2′ attack of the chiral phosphine organocatalyst on 2-(4H-benzo[d][1,3]oxazin-4-yl)acrylates generated the key phosphine-containing dipolar intermediates, and the subsequent formal cycloaddition with isocyanates furnished a broad scope of 3,4-dihydroquinazolin-2-ones in 60–84% yields with 61–92% ee.
显示更多 [+] 显示较少 [-]AGROVOC关键词
书目信息
出版者
John Wiley & Sons, Ltd
其它主题
Acrylates; Enantioselectivity; Organocatalysts; Cycloaddition reactions
语言
英语
类型
Journal Article; Text
2024-02-29
MODS