A formal synthesis of valiolamine from myo-inositol

Jagdhane, Rajendra C.; Shashidhar, Mysore S.

A formal synthesis of valiolamine from myo-inositol

2011

Jagdhane, Rajendra C. | Shashidhar, Mysore S.

An efficient formal synthesis of racemic valiolamine starting from readily available myo-inositol is reported. In all the synthetic steps only one regioisomer is formed, which circumvents laborious purification of products. Regioselective benzylation of myo-inositol orthoformate, super-hydride mediated deoxygenation of a cyclitol derivative and stereoselective addition of dichloromethyllithium to an inosose are the key reactions in the synthesis.

显示更多 [+]