Optimized Synthesis of new LE404-derived azecine-prodrugs
2017
Zergiebel, Stephanie | Arndt, Hans-Dieter | Seeling, Andreas
Dibenzoazecines represent a class of high-affinity dopamine and serotonin receptor antagonists. The former synthesis of the lead structure 7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecin-3-ol (LE404) has been 5 steps with a total yield of 13%. The present work enabled the synthesis of LE404 with a much higher yield. Based on this research, further azecin derivatives were synthesized with the aim to improve pharmacokinetic parameters.
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书目信息
出版者
Oxford University Press
其它主题
Le404; Prodrugs; Azecines; Antagonists; Serotonin receptors
语言
英语
注释
Pre-press version
类型
Journal Article; Text
2024-02-29
MODS