Hyperglycemic hyperosmolar syndrome in a domestic ferret (Mustela putorius furo) following a partial pancreatectomy
2020
Pierce, Karra N. | Lee, Samuel | Pacheco, Rebecca | Sadar, Miranda J.
Insulinoma is common for the presentation of ferrets to veterinarians. This beta-cell adenocarcinoma secrets insulin resulting in hyperinsulinemia and hypoglycemia. Medical and surgical options exist for treatment of insulinoma in the ferret. Surgical treatment is considered gold standard, and there are few reports of complications associated with this procedure.A 4-year-old, 1.4 kg, male castrated domestic ferret (Mustela putorius furo) was diagnosed with hyperglycemic hyperosmolar syndrome (HHS) following a partial pancreatectomy. The ferret had historically been diagnosed with insulinoma and was medically managed for 5 months. When the ferret became refractory to medical treatments, including prednisolone and diazoxide, the owners elected to pursue surgery for a partial pancreatectomy. Following surgery, the ferret's mentation progressed from mentally dull to obtunded and it was persistently hyperglycemic. The ferret was hospitalized for 96 hours after surgery and during this time, developed hypokalemia followed by hyperkalemia, azotemia, and persistent hyperglycemia. It was calculated to have a serum osmolality in excess of 350 mOsm, a hyperglycemia in excess of 600 mg/dL, and an absence of ketonuria, which meets the criteria for a diagnosis of HHS in canine and feline patients.This is the first report of HHS in a domestic ferret, and this should be considered as a differential diagnosis in persistently hyperglycemic ferrets that have undergone a partial pancreatectomy.
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