Enhanced ratiometric fluorescent indicators for magnesium based on azoles of the heavier chalcogens

Afzal, Mohammad S.; Pitteloud, Jean-Philippe; Buccella, Daniela

Enhanced ratiometric fluorescent indicators for magnesium based on azoles of the heavier chalcogens

2014

Afzal, Mohammad S. | Pitteloud, Jean-Philippe | Buccella, Daniela

Red-shifted fluorescent indicators for magnesium were developed by incorporation of sulfur or selenium in the azole moiety of ‘fura’ fluorophores. Single atom replacement in the acceptor of these ITC probes affords longer excitation and emission wavelengths as well as greater separation between excitation bands, valuable for ratiometric intracellular Mg²⁺ imaging.

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