Convenient and rapid strategies towards 6-(hetero)aryl pyridylmethylamines: first catalytic issues
2015
Requet, Alexandre | Yalgin, Hasret | Prim, Damien
The convenient preparation of new pyridylmethylamines is described using a short two step sequence. The first step involved the straightforward microwave-assisted construction of 6-aryl and 6-heteroaryl pyridine scaffolds bearing carboxaldehyde and nitrile fragments. The pendant arm comprising a second nitrogen atom by mean of amine and oxazoline moieties is installed in the second step. Finally, a first entry towards catalytic activity is given. In this context, modification of the ligand pattern and steric crowding around the central pyridine ring is examined and led to modest to fair ee’s in the construction of binaphthyl substrates.
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