Synthesis of polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth

Thévenin, Marion; Thoret, Sylviane; Grellier, Philippe; Dubois, Joëlle

Synthesis of polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth

2013

Thévenin, Marion | Thoret, Sylviane | Grellier, Philippe | Dubois, Joëlle

A series of polysubstituted benzofuran derivatives was easily and rapidly prepared using a tandem Sonogashira coupling/cyclization reaction. Subsequent acylation afforded a small library of 39 new compounds that were assayed in cellulo on Plasmodium falciparum and Trypanosoma brucei parasites. Some of them exhibited good inhibitory activity on T. brucei proliferation.

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