Photothermal effect enhancing graphene quantum dots/semiconducting polymer/nanozyme-mediated cancer catalytic therapy
2021
Hu, Linyu | Sun, Weiyi | Tang, Yuying | Li, Su | Zhang, Bei | Sun, Xuetong | Ji, Wenwen | Ma, Lijuan | Deng, Haishan | Han, Shuying | Zhu, Dong
Graphene quantum dots (GQDs) with intrinsic enzyme-like activity have attracted great attention in the biomedical field. The application mainly focused on biosensing area, but the anti-tumor study was restricted due to the poor catalytic efficacy of GQDs. Herein, we introduce an enhancing nanozyme using graphene quantum dots/semiconducting polymer nanocomposites (GQD-SPNs) which provide enhanced nanozyme activity for tumor therapy through photothermal effect. Near infrared irradiation guide local temperature increasing at the tumor and boost the hydroxyl radicals (▪OH) generation, to synergize with generated ¹O₂ and heat for better cancer therapy in Hela tumor bearing-mice. The present GQD-SPNs may turn on great opportunities for the enhanced nanozymes to cancer catalytic therapy.
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