Pharmacokinetics/pharmacodynamics of marbofloxacin in a Pasteurella multocida serious murine lung infection model
2015
Qu, Ying | Qiu, Zhenzhen | Cao, Changfu | Lu, Yan | Sun, Meizhen | Liang, Chaoping | Zeng, Zhenling
BACKGROUND: Marbofloxacin is a third-generation fluoroquinolone developed solely for veterinary medicine with a broad spectrum of antibacterial activity against some Gram-positive and most Gram-negative bacteria, including the bovine respiratory tract pathogen, Pasteurella multocida. The objective of our study was to elucidate the pharmacokinetics and pharmacodynamics of marbofloxacin in a Pasteurella multocida infected murine lung model, and to estimate the magnitudes of pharmacokinetics-pharmacodynamics parameters associated with various effects. RESULTS: The pharmacokinetic studies revealed marbofloxacin kinetics in infected mice were linear over a dose ranging from 1.25 to 10 mg/kg of body weight. The protein binding in the plasma of neutropenic infected mice was 29.77 %. The magnitudes of the ratio of the free-drug area under the concentration-time curve over 24 h to MIC (fAUC₀₋₂₄ₕ/MIC) associated with static effect, a 2 log₁₀ reduction and a 3 log₁₀ reduction of bacterial counts were 40.84, 139.34, and 278.08 h, respectively. CONCLUSIONS: Based on the dose range study, marbofloxacin exhibited concentration-dependent killing and the fAUC/MIC was the PK/PD index that correlated best with efficacy (R² = 83 %). On the basis of a bactericidal effect goal of fAUC₀₋₂₄ₕ/MIC of 278.08 h, if marbofloxacin is used for the treatment of P. multocida serious lung infection with an MIC₉₀ of 0.12 μg/ml, the current dose (2 mg/kg) would fail to achieve a bactericidal effect. It would benefit from higher doses (4 ~ 6 mg/kg) than those commonly used in clinical practice.
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