Pathophysiological effects of low dietary phosphorus in pigs
2001
Riond, J.L. | Wanner, M. | Coste, H. | Parvu, G.
The homeostasis of inorganic phosphate (Pi) is regulated by parathyroid hormone (PTH), 1,25-dihydroxy-vitamin D (1,25(OH)2D), and Pi itself in the intestine, kidney, and bone in all the mammalian species studied. Determinations of the serum concentrations of PTH, 1,25(OH)2D and osteocalcin were done in 82 southern Romanian Landrace pigs originating from three herds with dietary Pi deficiency. Serum Pi concentrations were negatively correlated with those of 1,25 (OH)2D. In lactating animals and sucklings, the linear relationships between Pi and 1,25 (OH)2D were not present. Serum Pi concentrations were positively correlated with those of PTH. In lactating animals and young pigs, the linear relationships between Pi and PTH were not evident. PTH and 1,25 (OH)2D concentrations were negatively correlated. The serum concentrations of 1,25 (OH)2D and osteocalcin were positively correlated. Milk Pi concentrations ranging from 3.10 to 7.49 mmol/L were correlated positively with urinary Pi concentrations ranging from 0.26 to 11.37 mmol/L. In conclusion, similarly to other species, Pi homeostasis is achieved in pigs by feedback mechanisms between Pi, PTH and 1,25 (OH)2D and osteocalcin production is induced by 1,25 (OH)2D. The effect of lactation on Pi homeostasis remains to be explored.
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