Absolute configuration assignment of an unusual homoisoflavanone from Polygonum ferrugineum using a combination of chiroptical methods

Batista, João M.; Wang, Bo; Castelli, María V.; Blanch, Ewan W.; López, Silvia N.

Absolute configuration assignment of an unusual homoisoflavanone from Polygonum ferrugineum using a combination of chiroptical methods

2015

Batista, João M. | Wang, Bo | Castelli, María V. | Blanch, Ewan W. | López, Silvia N.

The absolute configuration of the homoisoflavanone 5,7-dihydroxy-6-methoxy-3-(9-hydroxy-phenylmethyl)-chroman-4-one (1), found in Polygonum species, has been determined as 3R,9R by using a combination of electronic and vibrational chiroptical spectroscopic methods. The experimental spectra were interpreted with the aid of density functional theory calculations. The risks of relying upon a single method for stereochemical characterization of natural products are discussed.

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