Metal-free, base catalyzed oxidative amination and denitration reaction: regioselective synthesis of 3-arylimidazo[1,2-a]pyridines

Devi, Elango Sankari; Alanthadka, Anitha; Nagarajan, Subbiah; Sridharan, Vellaisamy; Maheswari, Chockalingam Uma

Metal-free, base catalyzed oxidative amination and denitration reaction: regioselective synthesis of 3-arylimidazo[1,2-a]pyridines

2018

Devi, Elango Sankari | Alanthadka, Anitha | Nagarajan, Subbiah | Sridharan, Vellaisamy | Maheswari, Chockalingam Uma

A metal-free, regioselective strategy for the synthesis of 3-arylimidazo[1,2-a]pyridines from β-nitrostyrenes and 2-aminopyridines using triethylamine as the catalyst and H2O2 (30% aq.) as the oxidant is reported. The use of an inexpensive base and facile reaction conditions make this strategy a practical alternative for the synthesis of 3-arylimidazo[1,2-a]pyridines.

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