Efficacy of Different Hexacyanoferrates(II) in Inhibiting the Intestinal Absorption of Radiocaesium in Rats
2014
Dresow, Bernd | Nielsen, Peter | Heinrich, Hellmuth C.
The inhibitory effect of various oral doses of different hexacyanoferrate(II) compounds (HCF) and the influence of the time interval of HCF-administration on intestinal ¹³⁴Cs-absorption was studied in rats. Optimum inhibition was obtained by administration of HCF together with or 2 min before oral ¹³⁴Cs loading. Using appropriate low amounts (0.1 -0.5 mg) of the different HCF compounds, the inhibitory effect increased in the sequence KZnHCF < KCuHCF < FeHCF < KCoHCF = KNiHCF < NH₄FeHCF = KFeHCF . Oral administration of 5 mg (0.5 mg) of KFeHCF , together with ¹³⁴CsCl loading, reduces ¹³⁴Cs-absorption from 41 % (control) to 0.8% (2.8%).Zinc-, copper-, cobalt, and nickel hexacyanoferrates(II), despite showing a high caesium sorption capacity in vitro, were less effective in rats and are not suited for in vivo application, also because they may produce toxic side effects. As a consequence, the orally administered colloidal-soluble iron (III) hexacyanoferrates(II) (NH₄Fe[Fe(CN)₆] and KFe[Fe(CN)₆]) have to be considered as the most valuable countermeasure against radiocaesium absorption for humans and domestic animals in the case of a severe nuclear accident in the future.Manganese oxide, a non-hexacyanoferrate(II) compound with known in vitro caesium binding capacity, showed no inhibitory effect on radiocaesium absorption in rats.
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