Efficient PhB(OH)2-catalyzed one-pot synthesis of 3-substituted isoindolin-1-ones and isobenzofuran-1(3H)-ones under solvent free conditions
2018
Palillero-Cisneros, Angel | Bedolla-Medrano, Mercedes | Ordóñez, Mario
An efficient and practical one-pot synthesis of 3-substituted isoindolin-1-ones and isobenzofuran-1(3H)-ones has been developed under solvent free-conditions using non-toxic and cheap phenylboronic acid as excellent catalyst. This strategy involves the sequential two-step Mannich/lactamization cascade reaction of inexpensive 2-formylbenzoic acid with primary amines and a wide variety of ketones, and an aldol/lactonization cascade reaction of 2-formylbenzoic acid with a broad range of ketones.
显示更多 [+] 显示较少 [-]AGROVOC关键词
书目信息
出版者
Elsevier Ltd
其它主题
Mannich/lactamization; Primary amines; Isobenzofuran-1-ones; Aldol/lactonization; Isoindolin-1-ones; Phenylboronic acid
语言
英语
类型
Journal Article; Text
2024-02-29
MODS