Engineering design and mechanistic mathematical models: Standpoint on cutting edge drug delivery
2018
Parmar, Ankush | Sharma, Shweta
The process of drug dissolution depends upon a number of physical phenomenon i.e. wetting of the particle's surface, breakdown of solid state bonds, solvation, diffusion (through the liquid unstirred boundary layer surrounding the particle), and convection. Development of less complex theories and appropriate mathematical equations can be pioneer in describing the drug dissolution kinetics. The mathematical models simplify the analysis and optimize the design of therapeutic device to yield information on the efficacy of release models.For controlled release drug delivery applications, numerous PLGA based micro and nanospheres have been extensively studied. In order to describe the mechanisms involved during PLGA degradation, erosion and drug release from the bulk polymer, various mathematical models have been proposed. Along with describing the current state of art of mathematical modeling in drug dissolution, the review article addresses the role of autocatalysis in mass transport and chemical reaction phenomenon of drug delivery from polymeric drug delivery systems.
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