M6ADD: a comprehensive database of m⁶A modifications in diseases
2021
Zhou, Dianshuang | Wang, Hongli | Bi, Fanqi | Xing, Jie | Gu, Yue | Wang, Cong | Zhang, Menyan | Huang, Yan | Zeng, Jiaqi | Wu, Qiong | Zhang, Yan
N6-methyladenosine (m⁶A) modification is an important regulatory factor affecting diseases, including multiple cancers and it is a developing direction for targeted disease therapy. Here, we present the M6ADD (m⁶A-diseases database) database, a public data resource containing manually curated data on potential m⁶A-disease associations for which some experimental evidence is available; the related high-throughput sequencing data are also provided and analysed by using different computational methods. To give researchers a tool to query the m6A modification data, the M6ADD was designed as a web-based comprehensive resource focusing on the collection, storage and online analysis of m6A modifications, aimed at exploring the associations between m6A modification and gene disorders and diseases. The M6ADD includes 222 experimentally confirmed m⁶A-disease associations, involving 59 diseases from a review of more than 2000 published papers. The M6ADD also includes 409,229 m⁶A-disease associations obtained by computational and statistical methods from 30 high-throughput sequencing datasets. In addition, we provide data on 5239 potential m⁶A regulatory proteins related to 24 cancers based on network analysis prediction methods. In addition, we have developed a tool to explore the function of m⁶A-modified genes through the protein–protein interaction networks. The M6ADD can be accessed at http://m6add.edbc.org/.
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