Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside
2012
Midtkandal, Rebecca R. | Redpath, Philip | Trammell, Samuel A.J. | Macdonald, Simon J.F. | Brenner, Charles | Migaud, Marie E.
2-Deoxy-C-nucleosides are a subcategory of C-nucleosides that has not been explored extensively, largely because the synthesis is less facile. Flexible synthetic procedures giving access to 2-deoxy-C-nucleosides are therefore of interest. To exemplify the versatility and highlight the limitations of a synthetic route recently developed to that effect, the first synthesis of 2-deoxy benzamide riboside is reported. Biological properties of this novel C-nucleoside are also discussed.
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