LINE-1 distribution in six rodent genomes follow a species-specific pattern
2016
VIEIRA-DA-SILVA, A. | ADEGA, F. | GUEDES-PINTO, H. | CHAVES, R.
L1 distribution in mammal’s genomes is yet a huge riddle. However, these repetitive sequences were already found in all chromosomic regions, and in general, they seem to be nonrandomly distributed in the genome. It also seems that after insertion and when they are not deleterious, they are always involved in dynamic processes occurring on that particular chromosomic region. Furthermore, it seems that large-scale genome rearrangements and L1 activity and accumulation are somehow interconnected. In the present study, we analysed L1 genomic distribution in Tatera gambiana (Muridae, Gerbillinae), Acomys sp. (Muridae, Deomyinae), Cricetomys sp. (Nesomyidae, Cricetomyinae), Microtus arvalis (Cricetidae, Arvicolinae), Phodopus roborovskii and P. sungorus (Cricetidae, Cricetinae). All the species studied here seems to exhibit a species-specific pattern. Possible mechanisms, and processes involved in L1 distribution and preferential accumulation in certain regions are discussed.
显示更多 [+] 显示较少 [-]