Facile preparation of shell crosslinked micelles for redox-responsive anticancer drug release

Gao, Lilong; Luo, Qiaojie; Wang, Ying; Du, Hong; Li, Xiaodong; Shen, Zhiquan; Zhu, Weipu

Facile preparation of shell crosslinked micelles for redox-responsive anticancer drug release

2013

We report a “one-pot” method to synthesize an amphiphilic triblock copolymer with multiple pendant mercapto groups in the hydrophilic block. Shell crosslinked micelles were prepared in a facile manner via the self-assembly of this copolymer in aqueous solution and crosslinking of the micellar shell by H₂O₂. These shell crosslinked micelles show rapid bioreductive responsiveness for anticancer drug release.

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