Expanded scope of Griesbaum co-ozonolysis for the preparation of structurally diverse sensors of ferrous iron

Chen, Jun; Gonciarz, Ryan L.; Renslo, Adam R.

Expanded scope of Griesbaum co-ozonolysis for the preparation of structurally diverse sensors of ferrous iron

2021

Chen, Jun | Gonciarz, Ryan L. | Renslo, Adam R.

Sterically shielded 1,2,4-trioxolanes prepared by Griesbaum co-ozonolysis have been utilized as chemical sensors of ferrous iron in several recently described chemical probes of labile iron. Here we report optimized conditions for co-ozonolysis that proceed efficiently and with high diastereoselectivity across an expanded range of substrates, and should enable a new generation of labile iron probes with altered reaction kinetics and physicochemical properties.

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