Potential of di-aldehyde cellulose for sustained release of oxytetracycline: A pharmacokinetic study
2019
Mishra, Disha | Jyotshna, | Singh, Arjun | Chanda, D. | Shanker, K. | Khare, Puja
This study focused on the in-vivo sustained release of oxytetracycline (OTC) loaded on di-aldehyde cellulose (DAC). The periodate oxidation method was used for the synthesis of DAC. The prepared DAC-OTC material was characterized by different techniques such as Scanning electron microscopy (SEM), Fourier transforms infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Transmission electron microscopy (TEM) and particle size analyzer. The pharmacokinetic studies were performed on DAC-OTC composite system and commercial tablet (COTA). The results of pharmacokinetic studies demonstrated that DAC-OTC exhibited higher area under the curve (AUC) (482.8 μghmL−1) as compared to COTA (90.72 μghmL−1). DAC-OTC composite system has double compartment pattern with improvement in mean residing time (MRT) and area under moment curve (AUMC0-∞) than the commercial tablet (2.8 and 15.13 folds higher, respectively). Swelling index of DAC-OTC at different pH and pKa of OTC release imply that controlled in-vivo release in DAC-OTC composite system could be due to the simultaneous occurrence of the covalent and hydrogen bond between OTC and di-aldehyde cellulose. These results indicate that di-aldehyde cellulose may improve the in-vivo bioavailability of OTC.
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