Immune-mediated hemolysis after administration of human intravenous immunoglobulin in a dog: a case report
2023
Kim, M.J. | Kim, Y.J. | Bae, H.A. | Jung, R.K. | Kang, M.J. | Cha, S.M. | Cho, K.W. | Jung, D.I. | Yu, D.H.
A 10-year-old spayed female Maltese presented with purpura and hematemesis. Initial laboratory evaluation revealed immune-mediated thrombocytopenia, but evidence of hemolytic anemia was not identified. Three milligrams of human intravenous immunoglobulin (hIVIG) was administered for 3 hours following prednisolone and mycophenolate mofetil. A pale mucous membrane was identified, and the packed cell volume decreased by 3%. Blood film examination revealed significant spherocytosis with auto-agglutination. Blood transfusions and immunosuppression were continued for 4 days, and hIVIG was discontinued. This report describes a case of increased immune-mediated hemolysis after hIVIG administration, possibly due to new-onset immune-mediated hemolytic anemia or enhanced immunogenicity.
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