Small molecule ectonucleotide pyrophosphatase/phosphodiesterase 1 inhibitors in cancer immunotherapy for harnessing innate immunity
2023
Choi, Junwon
Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) was recently identified as a major hydrolase of an endogenous stimulator of interferon genes (STING) agonist, 20,30-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP). ENPP1 is a promising therapeutic target in cancer immunotherapy, in which the inhibition of ENPP1 enhances anticancer immunity via STING-mediated innate immune activation. This review highlights the role of ENPP1 in innate immunity and the recent discovery of small molecule ENPP1 inhibitors as immunomodulators in cancer immunotherapy.
显示更多 [+] 显示较少 [-]AGROVOC关键词
书目信息
其它主题
Enpp1; Cancer immunotherapy; Cgamp; Enpp1 inhibitor; Sting
语言
英语
类型
Journal Article; Journal Part; Text
2024-03-07
MODS
在Google Scholar上查找
如果您发现与此记录相关的任何错误信息，请联系 [email protected]