A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes
2022
Seal, Snehaa | Henry, Mathilde | Pajot, Clementine | Holuka, Cyrielle | Bailbe, Danielle | Movassat, Jamileh | Darnaudery, Muriel | Turner, Jonathan | Université du Luxembourg = University of Luxembourg = Universität Luxemburg (uni.lu) | Luxembourg Institute of Health (LIH) | Nutrition et Neurobiologie intégrée (NutriNeuro) ; Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité) | Fonds National de la Recherche Luxembourg | Departement Alimentation Humaine, Institut National de la Recherche Agronomique | ANR-17-CE37-0020,MADAM,Diabète maternel et vulnérabilité neuropsychiatrique chez la descendance : rôle de la méthylation de l'ADN(2017)
International audience
显示更多 [+] 显示较少 [-]英语. Type-2 diabetes is a complex disorder that is now considered to have an immune component, with functional impairments in many immune cell types. Type-2 diabetes is often accompanied by comorbid obesity, which is associated with low grade inflammation. However,the immune status in Type-2 diabetes independent of obesity remains unclear. Goto-Kakizaki rats are a non-obese Type-2 diabetes model. The limited evidence available suggests that Goto-Kakizaki rats have a pro-inflammatory immune profile in pancreatic islets. Here we present a detailed overview of the adult Goto-Kakizaki rat immune system. Three converging lines of evidence: fewer pro-inflammatory cells, lower levels of circulating pro-inflammatory cytokines, and a clear downregulation of pro-inflammatory signalling in liver, muscle and adipose tissues indicate a limited pro-inflammatory baseline immune profile outside the pancreas. As Type-2 diabetes is frequently associated with obesity and adipocyte-released inflammatory mediators, the pro-inflammatory milieu seems not due to Type-2 diabetes per se; although this overall reduction of immune markers suggests marked immune dysfunction in Goto-Kakizaki rats.
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