Oxidative stress biomarkers are associated with visible clinical signs of a disease in frigatebird nestlings
2017
Sebastiano, Manrico | Eens, Marcel | Elgawad, Hamada, Abd | de Thoisy, Benoît | Lacoste, Vincent | Pineau, Kévin | Asard, Han | Chastel, Olivier | David Costantini, & | Universiteit Antwerpen = University of Antwerp | Beni-Suef University | Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française] ; Institut Pasteur de la Guyane ; Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur) | Groupe d’Etude et de Protection des Oiseaux en Guyane (GEPOG) | Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC) ; Institut National de la Recherche Agronomique (INRA)-La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS) | University of Glasgow | Evolution des régulations endocriniennes (ERE) ; Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS) | We are grateful to DEAL Guyane, the University of Antwerp, the Centre d’Etudes Biologiques de Chizé (CEBC) and the FWO (Fonds Wetenschappelijk Onderzoek), who funded field and oxidative stress analyses. Moreover, we are grateful to the GEPOG (Groupe d’Etude et de Protection des Oiseaux en Guyane) and to the ONCFS (Office national de la Chasse et de la Faune Sauvage), who manage the Grand Connétable Nature reserve since 2008, for their logistic support and access to the Grand Connetable Nature Reserve. We are especially grateful to Grand Connétable Nature staff (Amandine Bordin, Sébastien Renvoisé, Alain Alcide, and Louise Bétremieux) for their great help in the field. We also thank Giulia Casasole (University of Antwerp) and Damien Donato (Institut Pasteur de la Guyane) for their help with the laboratory analysis. We also thank four anonymous reviewers for providing comments that helped us to improve the presentation of our work.
International audience
显示更多 [+] 显示较少 [-]英语. Infectious diseases are one of the most common threats for both domestic and wild animals, but little is known about the effects on the physiological condition and survival of wild animals. Here, we have tested for the first time in a wild vertebrate facing a viral disease possibly due to herpesvirus (i) whether nestlings with either low levels of oxidative damage or high levels of antioxidant protection are less susceptible to develop visible clinical signs, (ii) whether the disease is associated with the nestlings' oxidative status, (iii) whether the association between the disease and oxidative status is similar between males and females (iv), and whether cloacal and tracheal swabs might be used to detect herpesvirus. To address our questions, we took advantage of a population of Magnificent frigatebirds (Fregata magnificens) whose nestlings have experienced high mortality rates in recent times. Our work shows that (i) blood lipid oxidative damage is associated with observable clinical signs and survival probabilities of nestling frigatebirds, and (ii) that high glutathione levels in red blood cells are associated with the emergence of visible clinical signs of the disease. Our work provides evidence that differences in the oxidative status of nestlings might underlie individual health and survival.
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