Analyses of pig genomes provide insight into porcine demography and evolution
2012
A. M. Groenen, Martien | Archibald, Alan L. | Uenishi, Hirohide | Tuggle, Christopher K. | Takeuchi, Yasuhiro | Rothschild, Max F. | Rogel Gaillard, Claire | Park, Chankyu | Milan, Denis | Megens, Hendrik-Jan | Li, Shengting | Larkin, Denis M. | Kim, Heebal | Frantz, Laurent A. F. | Caccamo, Mario | Ahn, Hyeonju | Aken, Bronwen L. | Anselmo, Anna | Anthon, Christian | Auvil, Loretta | Badaoui, Bouabid | W. Beattie, Craig | Bendixen, Christian | Berman, Daniel | Blecha, Frank | Blomberg, Jonas | Bolund, Lars | Bosse, Mirte | Botti, Sara | Bujie, Zhan | Bystrom, Megan | Capitanu, Boris | Carvalho-Silva, Denise | Chardon, Patrick | Chen, Celine | Cheng, Ryan | Choi, Sang-Haeng | Chow, William | C. Clark, Richard | Clee, Christopher | P. M. A. Crooijmans, Richard | D. Dawson, Harry | Dehais, Patrice | de Sapio, Fioravante | Dibbits, Bert | Drou, Nizar | Du, Zhi-Qiang | Eversole, Kellye | Fadista, João | Fairley, Susan | Faraut, Thomas | J. Faulkner, Geoffrey | E. Fowler, Katie | Fredholm, Merete | Fritz, Eric | G. R. Gilbert, James | Giuffra, Elisabetta | Gorodkin, Jan | K. Griffin, Darren | L. Harrow, Jennifer | Hayward, Alexander | Howe, Kerstin | Hu, Zhi-Liang | J. Humphray, Sean | Hunt, Toby | Hornshøj, Henrik | Jeon, Jin-Tae | Jern, Patric | Jones, Matthew | Jurka, Jerzy | Kanamori, Hiroyuki | Kapetanovic, Ronan | Kim, Jaebum | Kim, Jae-Hwan | Kim, Kyu-Won | Kim, Tae-Hun | Larson, Greger | Lee, Kyooyeol | Lee, Kyung-Tai | Leggett, Richard | A. Lewin, Harris | Li, Yingrui | Liu, Wansheng | E. Loveland, Jane | Lu, Yao | K. Lunney, Joan | Ma, Jian | Madsen, Ole | Mann, Katherine | Matthews, Lucy | Mclaren, Stuart | Morozumi, Takeya | P. Murtaugh, Michael | Narayan, Jitendra | Truong Nguyen, Dinh | Ni, Peixiang | Oh, Song-Jung | Onteru, Suneel | Panitz, Frank | Park, Eung-Woo | Park, Hong-Seog | Pascal, Géraldine | Paudel, Yogesh | Perez-Enciso, Miguel | Ramirez-Gonzalez, Ricardo | M. Reecy, James | Rodriguez-Zas, Sandra | A. Rohrer, Gary | Rund, Lauretta | Sang, Yongming | Schachtschneider, Kyle | G. Schraiber, Joshua | Schwartz, John | Scobie, Linda | Scott, Carol | Searle, Stephen | Servin, Bertrand | R. Southey, Bruce | Sperber, Goran | Stadler, Peter | V. Sweedler, Jonathan | Tafer, Hakim | Thomsen, Bo | Wali, Rashmi | Wang, Jian | Wang, Jun | White, Simon | Xu, Xun | Yerle, Martine, M. | Zhang, Guojie | Zhang, Jianguo | Zhang, Jie | Zhao, Shuhong | Rogers, Jane | Churcher, Carol | B. Schook, Lawrence | Laboratoire de radiobiologie et d'étude du génome (LREG) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Laboratoire de Génétique Cellulaire (LGC) ; Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT) | The Genome Analysis Centre (TGAC) | Parco Tecnologico Padano ; CERSA | Department of Clinical Genetics ; Odense University Hospital | The Wellcome Trust Sanger Institute [Cambridge] | Système d'Information des GENomes des Animaux d'Elevage (SIGENAE) ; Institut National de la Recherche Agronomique (INRA) | Faculty of Life Sciences, Division of Genetics and Bioinformatics ; Faculty of Life Science [Copenhagen] ; University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH) | Sainsbury Laboratory Cambridge University (SLCU) ; University of Cambridge [UK] (CAM) | HKU-BGI Bioinformatics Algorithms and Core Technology Research Laboratory [Hong Kong] ; The University of Hong Kong (HKU) | Beijing Genomics Institute [Shenzhen] (BGI) | Department of Biochemistry, University of Nijmegen, The Netherlands ; University of Nijmegen | Molecular Carcinogenesis [Sutton] ; Institute of cancer research | Physiologie de la reproduction et des comportements [Nouzilly] (PRC) ; Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS) | Université de Tours (UT) | Canadian Light Source Inc. ; University of Saskatchewan [Saskatoon, Canada] (U of S) | University of Auckland [Auckland] | ANR-07-GANI-0001,DELISUS,An integrated study of the haplotypic variability at the whole genome level on animals finely phenotyped from French porcine populations(2007) | European Project: LSHB-CT-2006-037377 | European Project: 249894,EC:FP7:ERC,ERC-2009-AdG,SELSWEEP(2010) | European Project: 38710,SABRE | European Project: 222664,EC:FP7:KBBE,FP7-KBBE-2007-2A,QUANTOMICS(2009)
Chantier qualité GA "Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-Access "
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显示更多 [+] 显示较少 [-]英语. For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars ~1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfaction exhibit fast evolution. Pigs have the largest repertoire of functional olfactory receptor genes, reflecting the importance of smell in this scavenging animal. The pig genome sequence provides an important resource for further improvements of this important livestock species, and our identification of many putative disease-causing variants extends the potential of the pig as a biomedical model
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