Influence of Humans on Evolution and Mobilization of Environmental Antibiotic Resistome
2013
Gaze, William, H. | Krone, Stephen | Larsson, Joachim, D.G. | Li, Xian-Zhi | Robinson, Joseph, A. | Simonet, Pascal | Smalla, Kornelia | Timinouni, Mohammed | Topp, Edward | Wellington, Elizabeth M.H. | Wright, Gerard, D. | Zhu, Yong-Guan | University of Exeter | Göteborgs Universitet = University of Gothenburg (GU) | Ampère (AMPERE) ; École Centrale de Lyon (ECL) ; Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon) ; Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Institute for Plant Virology, Microbiology and Biosafety ; Federal Biological Research Centre for Agriculture and Forestry, Berlin and Braunschweig (BBA) | Institut Pasteur du Maroc ; Pasteur Network (Réseau International des Instituts Pasteur) | Agriculture and Agri-Food (AAFC) | Department of Biological Sciences [Coventry] ; University of Warwick [Coventry] | Department of Biology [McMaster] ; McMaster University [Hamilton, Ontario]
International audience
显示更多 [+] 显示较少 [-]英语. The clinical failure of antimicrobial drugs that were previously effective in controlling infectious disease is a tragedy of increasing magnitude that gravely affects human health. This resistance by pathogens is often the endpoint of an evolutionary process that began billions of years ago in non-disease-causing microorganisms. This environmental resistome, its mobilization, and the conditions that facilitate its entry into human pathogens are at the heart of the current public health crisis in antibiotic resistance. Understanding the origins, evolution, and mechanisms of transfer of resistance elements is vital to our ability to adequately address this public health issue.
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