Advances on plant-pathogen interactions from molecular toward systems biology perspectives
2017
Peyraud, Rémi | Dubiella, Ullrich Rainer | Barbacci, Adelin | Genin, Stéphane | Raffaele, Sylvain | Roby, Dominique | Laboratoire des interactions plantes micro-organismes (LIPM) ; Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS) | Plant Health & Environment Division of INRA ; ANR : ANR-14-CE19-0024 ; European Research Council : ERC-StG-336808 ; Marie Slodowska-Curie Actions of the European Commission : CIG-334036 ; EMBO : ALTF 1627-2011 ; GA-2010-267146 ; French Laboratory of Excellence project 'TULIP' : ANR-10-LABX-41 | ANR-10-LABX-0041,TULIP,Towards a Unified theory of biotic Interactions: the roLe of environmental(2010) | ANR-14-CE19-0024,RIPOSTE,Exploitation de la variabilité de la résistance quantiattive aux agents pathogènes pour l'amélioration de la tolérance aux maladies des espèces cultivées(2014) | European Project: 336808
autre Projet Européen : 3334036, SEPARATE Identification of Sclerotinia sclerotiorum Effector Proteins mediating virulence on Arabidopsis thaliana ecotypes
显示更多 [+] 显示较少 [-]英语. In the past 2 decades, progress in molecular analyses of the plant immune system has revealed key ele-ments of a complex response network. Current paradigms depict the interaction of pathogen-secreted mole-cules with host target molecules leading to the activation of multiple plant response pathways. Furtherresearch will be required to fully understand how these responses are integrated in space and time, andexploit this knowledge in agriculture. In this review, we highlight systems biology as a promising approachto reveal properties of molecular plant–pathogen interactions and predict the outcome of such interactions.We first illustrate a few key concepts in plant immunity with a network and systems biology perspective.Next, we present some basic principles of systems biology and show how they allow integrating multi-omics data and predict cell phenotypes. We identify challenges for systems biology of plant–pathogen inter-actions, including the reconstruction of multiscale mechanistic models and the connection of host andpathogen models. Finally, we outline studies on resistance durability through the robustness of immunesystem networks, the identification of trade-offs between immunity and growth and in silico plant–patho-gen co-evolution as exciting perspectives in the field. We conclude that the development of sophisticatedmodels of plant diseases incorporating plant, pathogen and climate properties represent a major challengefor agriculture in the future.
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