Interferons and interferon receptors in the channel catfish, Ictalurus punctatus
2022
Quiniou, Sylvie M.A. | Crider, Jonathan | Felch, Kristianna | Bengtén, Eva | Boudinot, Pierre | USDA-ARS : Agricultural Research Service | University of Mississippi Medical Center (UMMC) | Virologie et Immunologie Moléculaires (VIM (UR 0892)) ; Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | P20GM104357; P20GM103476; 6066-31000-016-00D; National Institutes of Health, NIH; National Institute of General Medical Sciences, NIGMS; U.S. Department of Agriculture, USDA; National Institute of Food and Agriculture, NIFA: 2020-67034-31895 | SQ is supported by funds from the USDA-Agricultural Research Service in house project number 6066-31000-016-00D. PB is supported by institutional grants of INRAE. JC is supported by USDA-National Institute of Food and Agriculture grant (number 2020-67034-31895). Mention of trade names or commercial products in this publication is solely for the purpose of providing specific information and does not imply recommendation or endorsement by the U.S. Department of Agriculture. USDA is an equal opportunity provider and employer. This work also benefited from services at the UMMC Genomics Facility. The work performed through the UMMC Molecular and Genomics Facility is supported, in part, by funds from the NIGMS, including Mississippi INBRE (P20GM103476) and Obesity, Cardiorenal and Metabolic Diseases- COBRE (P20GM104357). The content of the manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. We thank Professor Melanie Wilson for proofreading the article. | SQ is supported by funds from the USDA-Agricultural Research Service in house project number 6066-31000-016-00D . PB is supported by institutional grants of INRAE. JC is supported by USDA- National Institute of Food and Agriculture grant (number 2020-67034-31895 ). Mention of trade names or commercial products in this publication is solely for the purpose of providing specific information and does not imply recommendation or endorsement by the U.S. Department of Agriculture. USDA is an equal opportunity provider and employer. This work also benefited from services at the UMMC Genomics Facility. The work performed through the UMMC Molecular and Genomics Facility is supported, in part, by funds from the NIGMS , including Mississippi INBRE ( P20GM103476 ) and Obesity, Cardiorenal and Metabolic Diseases- COBRE ( P20GM104357 ). The content of the manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. We thank Professor Melanie Wilson for proofreading the article.
International audience
显示更多 [+] 显示较少 [-]英语. In this work, we describe the complete repertoire of channel catfish, Ictalurus punctatus, IFNs and IFN receptor genes. Based on multiple genomic and transcriptomic resources we identified 16 type I IFN genes, which represent the six type I IFN subgroups previously defined in salmonids (a-f.) No representatives of subgroup h previously only found in percomorphs were identified. An expansion in copy numbers of subgroup d IFN genes was of particular interest, as this has not been reported in other fish species to date. Furthermore, we confirmed the presence of two type II ifn genes encoding orthologs of IFNγ and the teleost-specific IFNγRel. Six homologs of IFN type I receptor genes were found in an array that shows conserved synteny with human chromosome 21. Three homologs of type II IFN receptor genes were also identified. These type I and type II receptor sequences are compatible with the dual type I IFN receptors, and the potentially more complex type II IFN receptors described in teleosts. Our data provide a comprehensive resource for future studies of channel catfish innate antiviral immunity.
显示更多 [+] 显示较少 [-]