Inhibitory activity of Detarium microcarpum extract
against hepatitis C virus

OLUGBUYIRO, J.A.O

Inhibitory activity of Detarium microcarpum extract against hepatitis C virus

2009

OLUGBUYIRO, J.A.O

Bioassay guided fractionation of the methanolic extract of Detarium microcarpum Guill using VLC and activity against hepatitis C virus in the Huh-7 Replicon assay was done. The active fraction MTH-1700 which demonstrated good inhibitory and selective potency (83.87%) against Hepatitis C Virus and comparable with 86.76% of the control; RS-446(2-Me-C) at a concentration of 10 µM was further fractionated by HPLC. Keywords: Detarium microcarpium; Anti-viral activity; Hepatitis; Cytotoxicity.

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