Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa
2021
Bataille, Arnaud | Salami, Habib | Seck, Ismaila | Lo, Modou, Moustapha | Ba, Aminata | Diop, Mariame | Sall, Baba | Faye, Coumba | Lo, Mbargou | Kaba, Lanceï | Sidime, Youssouf | Keyra, Mohamed | Diallo, Alpha, Oumar Sily | Niang, Mamadou | Sidibe, Cheick, Abou Kounta | Sery, Amadou | Dakouo, Martin | El Mamy, Ahmed, Bezeid | El Arbi, Ahmed, Salem | Barry, Yahya | Isselmou, Ekaterina | Habiboullah, Habiboullah | Lella, Abdellahi, Salem | Doumbia, Baba | Gueya, Mohamed, Baba | Coste, Caroline | Squarzoni Diaw, Cécile | Kwiatek, Olivier | Libeau, Geneviève | Apolloni, Andrea | Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Département Systèmes Biologiques (Cirad-BIOS) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad) | Food and Agriculture Organization of the United Nations, Global Emergency Centre for Transboundary Animal Diseases (ECTAD) ; Food and Agriculture Organization of the United Nations [France] (FAO) ; Food and Agriculture Organization of the United Nations [Rome, Italie] (FAO)-Food and Agriculture Organization of the United Nations [Rome, Italie] (FAO) | Laboratoire National d'Elevage et de Recherches Vétérinaires [Dakar] (LNERV) ; Institut sénégalais de recherches agricoles [Dakar] (ISRA) | Direction des Services Vétérinaires de Dakar ; Ministère de l’Élevage et des Productions Animales [Dakar] | Institut Supérieur des Sciences et de Médecine Vétérinaire de Dalaba (ISSMV/D) | Laboratoire Central Vétérinaire [Bamako, Mali] | Office National de Recherche et de Développement de l’Elevage (ONARDEL) | Ar. B., O.K., H.S. and G.L. were supported by a grant from the European Commission Animal Health and Welfare European Research Area Network (https://ec.europa.eu/food/animals/health_en) for the IUEPPR Project "Improved Understanding of Epidemiology of PPR", in the framework of ANIHWA 2013. Ar. B., O.K. and G.L. were supported by a grant (SI2.756606) from the European Commission Directorate General for Health and Food Safety awarded to the European Union Reference Laboratory for Peste des Petits Ruminants (EURL-PPR). Ar.B., A.A., M.M.L. were supported by the European Commission through the International Fund for Agricultural Development (grant number 2000002577) and the CGIAR research program on Livestock. We thank all donors who support the work of the CGIAR research program on Livestock through their contributions to the CGIAR trust fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
International audience
显示更多 [+] 显示较少 [-]英语. Peste des petits ruminants (PPR) is a deadly viral disease that mainly affects small domestic ruminants. This disease threaten global food security and rural economy but its control is complicated notably because of extensive, poorly monitored animal movements in infected regions. Here we combined the largest PPR virus genetic and animal mobility network data ever collected in a single region to improve our understanding of PPR endemic transmission dynamics in West African countries. Phylogenetic analyses identified the presence of multiple PPRV genetic clades that may be considered as part of different transmission networks evolving in parallel in West Africa. A strong correlation was found between virus genetic distance and network-related distances. Viruses sampled within the same mobility communities are significantly more likely to belong to the same genetic clade. These results provide evidence for the importance of animal mobility in PPR transmission in the region. Some nodes of the network were associated with PPRV sequences belonging to different clades, representing potential "hotspots" for PPR circulation. Our results suggest that combining genetic and mobility network data could help identifying sites that are key for virus entrance and spread in specific areas. Such information could enhance our capacity to develop locally adapted control and surveillance strategies, using among other risk factors, information on animal mobility. As animals move so do viruses. The viral disease peste des petits ruminants (PPR) has a major impact on the livelihood of sheep and goat farmers across Africa, Middle-East and Asia. A global PPR eradication campaign is underway, but extensive movements of infected animals impede control efforts in many regions, such as West Africa. Here we show for the first time that PPR virus genetic data can be combined with information on animal mobility to identify routes of PPR circulation in Senegal and neighbouring countries. Such information can be used to design more efficient disease surveillance and control strategies adapted to local livestock farming practices.
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