Safety and efficacy of an inactivated Carbopol-adjuvanted Goose haemorrhagic polyomavirus vaccine for domestic geese
2010
Gelfi, Jacqueline | Pappalardo, Michael | Claverys, Carine | Peralta, Brigitte | Guerin, Jean-Luc | Interactions hôtes-agents pathogènes [Toulouse] (IHAP) ; Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT) | Pathologie aviaire et porcine ; École nationale vétérinaire d'Alfort (ENVA)
International audience
显示更多 [+] 显示较少 [-]英语. Hemorrhagic Nephritis Enteritis of Goose (HNEG) is an epizootic viral disease in domestic geese. Its agent is a polyomavirus, namely Goose haemorrhagic polyomavirus (GHPV). To help control the disease, an inactivated vaccine was developed, based on viral particles produced in goose kidney cells. Viral material was quantified using real-time quantitative PCR, inactivated with -propiolactone and adjuvanted with Carbopol, an acrylic acid polymer. Carbopol proved to be more immunogenic than aluminum hydroxide and was totally safe when administered to young goslings and breeders alike. Carbopol-adjuvanted vaccine induced a high serological response. Moreover, goslings hatched from vaccinated breeders were protected against viral challenge, indicating that maternally-derived neutralizing antibodies (MDA) were efficiently transferred. MDA were still detectable 15 days post-hatch. Clinical trials will be necessary to accurately evaluate a vaccine-based HNEG control strategy in field conditions
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