Optimized extraction conditions and alpha-glucosidase inhibitory activity of polyphenol from Terminalia catappa L.
2022
Nga, N.T.T. | Koshio, K.
The polyphenol extraction from Terminalia catappa L. (common name: tropical almond leaves) was optimized using the response surface methodology. A rotatable central composite design (RCCD) with three variables (material-to-solvent ratio, temperature and extraction time); consisting of 21 experimental runs with three replicates at the center minimal, and maximal factorial points was applied to describe the experimental data. The experimental results properly confirmed the constructed model. The optimized condition as follows: material-to-solvent ratio of 1:39.75, a temperature of 63.5 deg C, and an extraction time of 59.7 minutes. Five extractions were performed in parallel at the optimized conditions to validate the model. The experimental values highly agreed with the predicted value (P 0.05). The extract powder owned powerful effects against the alpha-glucosidase activity and can develop as a novel natural anti-diabetic agent.
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