A gene variation (rs12691) in the CCAT/enhancer binding protein alpha modulates glucose metabolism in metabolic syndrome
2013
Delgado-Lista, J. | Perez-Martinez, P. | García-Ríos, A. | Phillips, C. M. | Hall, W. | Gjelstad, I. M. F. | Lairon, Denis | Saris, W. | Kiec-Wilk, B. | Karlstrom, B. | Drevon, C. A. | Defoort, Catherine | Blaak, E. E. | Dembinska-Kiec, A. | Riserus, U. | Lovegrove, J. A. | Roche, H. M. | Lopez-Miranda, J. | Universidad de Córdoba = University of Córdoba [Córdoba] | CIBER Fisiopatol Obesidad & Nutr CIBERobn | University College Dublin [Dublin] (UCD) | University of Reading (UOR) | University of Oslo (UiO) | Oslo University Hospital [Oslo] | Nutrition, obésité et risque thrombotique (NORT) ; Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM) | Maastricht University [Maastricht] | Uniwersytet Jagielloński w Krakowie = Jagiellonian University = Université Jagellon de Cracovie (UJ) | Uppsala University | LIPGENE - an European Union [FOOD-CT-2003-505944]; Spanish Ministry of Science and Innovation [AGL 2004-07907, AGL2006-01979, AGL2009-12270, SAF07-62005, FIS PI10/01041, PI10/02412]; Consejeria de Economia, Innovacion y Ciencia, Proyectos de Investigacion de Excelencia; Junta de Andalucia [P06-CTS-01425, CTS5015, AGR922]; Consejeria de Salud, Junta de Andalucia [06/128, 07/43, PI0193/09, 06/129, 06/127, 0118/08, PI-0252/09, PI-0058/10]
International audience
显示更多 [+] 显示较少 [-]英语. Background and aims: CCAAT/enhancer-binding protein alpha (CEBPA) is a transcription factor involved in adipogenesis and energy homeostasis. Caloric restriction reduces CEBPA protein expression in patients with metabolic syndrome (MetS). A previous report linked rs12691 SNP in CEBPA to altered concentration of fasting triglycerides. Our objective was to assess the effects of rs12691 in glucose metabolism in Metabolic Syndrome (MetS) patients. Methods and results: Glucose metabolism was assessed by static (glucose, insulin, adiponectin, leptin and resistin plasma concentrations) and dynamic (disposition index, insulin sensitivity index, HOMA-IR and acute insulin response to glucose) indices, performed at baseline and after 12 weeks of 4 dietary interventions (high saturated fatty acid (SFA), high monounsaturated fatty acid (MUFA), low-fat and low-fat-high-n3 polyunsaturated fatty acid (PUFA)) in 486 subjects with MetS. Carriers of the minor A allele of rs12691 had altered disposition index (p = 0.0003), lower acute insulin response (p = 0.005) and a lower insulin sensitivity index (p = 0.025) indicating a lower insulin sensitivity and a lower insulin secretion, at baseline and at the end of the diets. Furthermore, A allele carriers displayed lower HDL concentration. Conclusion: The presence of the A allele of rs12691 influences glucose metabolism of MetS patients. Clinical Trials Registry number NCT00429195. (C) 2011 Elsevier B.V. All rights reserved.
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