An integrative eco-epidemiological analysis of West Nile Virus transmission
2017
Tran, Annelise | L'Ambert, G. | Balança, G. | Pradier, S. | Grosbois, V. | Balenghien, Thomas | Baldet, T. | Lecollinet, S. | Leblond, Agnès | Gaidet-Drapier, N. | Animal et gestion intégrée des risques (UPR AGIRs) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad) | Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad) | Groupement d'Intérêt Public Cyclotron Réunion Océan Indien ; Partenaires INRAE | Entente Interdépartementale pour la Démoustication du Littoral Méditerranéen | Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT) | Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA) | Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES) | Unité Mixte de Recherche d'Épidémiologie des maladies Animales et zoonotiques (UMR EPIA) ; Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)
International audience
显示更多 [+] 显示较少 [-]英语. West Nile disease, caused by the West Nile virus (WNV), is a mosquito-borne zoonotic disease affecting humans and horses that involves wild birds as amplifying hosts. The mechanisms of WNV transmission remain unclear in Europe where the occurrence of outbreaks has dramatically increased in recent years. We used a dataset on the competence, distribution, abundance, diversity and dispersal of wild bird hosts and mosquito vectors to test alternative hypotheses concerning the transmission of WNV in Southern France. We modelled the successive processes of introduction, amplification, dispersal and spillover of WNV to incidental hosts based on host-vector contact rates on various land cover types and over four seasons. We evaluated the relative importance of the mechanisms tested using two independent serological datasets of WNV antibodies collected in wild birds and horses. We found that the same transmission processes (seasonal virus introduction by migratory birds, Culex modestus mosquitoes as amplifying vectors, heterogeneity in avian host competence, absence of 'dilution effect') best explain the spatial variations in WNV seroprevalence in the two serological datasets. Our results provide new insights on the pathways of WNV introduction, amplification and spillover and the contribution of bird and mosquito species to WNV transmission in Southern France.
显示更多 [+] 显示较少 [-]