Potential physio-pathological effects of branched fatty acid esters of hydroxy fatty acids
2021
Benlebna, Melha | Balas, Laurence | Gaillet, Sylvie | Durand, Thierry | Coudray, Charles | Casas, François | Feillet‐coudray, Christine | Dynamique Musculaire et Métabolisme (DMEM) ; Université de Montpellier (UM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM) ; Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) | Algerian Ministry of Higher Education and Scientific Research
International audience
显示更多 [+] 显示较少 [-]英语. Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) are a new endogenous lipid class with recently uncovered interesting biological effects and which have been detected in food of plant and animal origins. Some FAHFAs can improve glucose tolerance and insulin sensitivity, stimulate insulin secretion, and exert anti-inflammatory effects. Other beneficial health effects have also been suggested, in particular against some cancers. FAHFAs could therefore be a potential therapeutic target for the treatment of numerous metabolic disorders such as type II diabetes, hepatic steatosis, cardiovascular diseases and various cancers. Their recent discovery has generated a great interest in the field of human health. This short review aims at bringing together the information available to date in the literature concerning their chemical synthesis, biosynthesis and degradation pathways as well as their potential physio-pathological beneficial effects.
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