Effects of <i>Indigofera suffruticosa</i> Miller (Wild indigo) leaves aqueous extract subacute supplementation in mice
2022
Rebeca Xavier Cunha | Weber Melo Nascimento | Joao Ricardhis Saturnino Oliveira | Alvaro Nobrega Melo Madureira | Ana Paula Sant’Anna Silva | Vera Lucia Menezes Lima
Supplementation with plant-based products is becoming more popular recently. This change in the supplementation market is related to larger benefits found in natural products, and fewer risks for chronic side effects found in synthetic products. Extracts rich in antioxidant properties and plants used by folk medicine are the main target to become a botanical supplement. <i>Indigofera suffruticosa</i> leaves aqueous extract (IsAE) was supplemented to mice diet for eleven days (50 mg/kg and 100 mg/kg, p.o.) to assess subacute toxicity and potential benefits. Body parameters were evaluated before and after supplementation. On the tenth day, mice were submitted to a forced swimming test to verify endurance. Lipids and glucose metabolism were also evaluated. During supplementation, no toxicity was observed. A mild decrease in body fat and weight was observed. There was no difference in swimming time among groups, but a significant increase was found for group 100 mg/kg after normalizing time by body weight. IsAE induces mild decrease (not statistically significant) in lipids and glucose levels. Thus, low doses of IsAE seem to be safe for usage, in the tested condition. In addition, 100 mg/kg of IsAE has the potential to improve endurance and might modulate fat and lipid concentrations of healthy mice in long-term supplementation.
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