<i>cmv1</i>-Mediated Resistance to CMV in Melon Can Be Overcome by Mixed Infections with Potyviruses
2023
Andrea Giordano | Inmaculada Ferriol | Juan José López-Moya | Ana Montserrat Martín-Hernández
Resistance to cucumber mosaic virus (CMV) strain LS in melon is controlled by the gene <i>cmv1</i>, which restricts phloem entry. In nature, CMV is commonly found in mixed infections, particularly with potyviruses, where a synergistic effect is frequently produced. We have explored the possibility that this synergism could help CMV-LS to overcome <i>cmv1</i>-mediated resistance. We demonstrate that during mixed infection with a potyvirus, CMV-LS is able to overcome <i>cmv1</i>-controlled resistance and develop a systemic infection and that this ability does not depend on an increased accumulation of CMV-LS in mechanically inoculated cotyledons. Likewise, during a mixed infection initiated by aphids, the natural vector of both cucumoviruses and potyviruses that can very efficiently inoculate plants with a low number of virions, CMV-LS also overcomes <i>cmv1</i>-controlled resistance. This indicates that in the presence of a potyvirus, even a very low amount of inoculum, can be sufficient to surpass the resistance and initiate the infection. These results indicate that there is an important risk for this resistance to be broken in nature as a consequence of mixed infections, and therefore, its deployment in elite cultivars would not be enough to ensure a long-lasting resistance.
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