Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015
2017
Maged Gomaa Hemida | Abdulmohsen Alnaeem | Daniel KW Chu | Ranawaka APM Perera | Samuel MS Chan | Faisal Almathen | Emily Yau | Brian CY Ng | Richard J Webby | Leo LM Poon | Malik Peiris
Two herds of dromedary camels were longitudinally sampled with nasal and rectal swabs and serum, between September 2014 and May 2015, and the samples were tested for Middle East Respiratory Syndrome (MERS) coronavirus RNA and antibodies. Evidence of MERS-CoV infection was confirmed in one herd on the basis of detection of virus RNA in nasal swabs from three camels and significant increases in the antibody titers from three others. The three viruses were genetically identical, thus indicating introduction of a single virus into this herd. There was evidence of reinfection of camels that were previously seropositive, thus suggesting that prior infection does not provide complete immunity from reinfection, a finding that is relevant to camel vaccination strategies as a means to prevent zoonotic transmission.Emerging Microbes & Infections (2017) 6, e56; doi:10.1038/emi.2017.44; published online 21 June 2017
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