Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans
2005
Edilson N Kaneshima | Marialba A Alves de Castro-Prado
Genotoxic effects of benznidazole were studied by the induction of homozygosis of genes previously present in heterozygous. UT448//A757 diploid strain was used in the benznidazole's recombinagenesis test. Although toxic effects on growth of colonies were not observed, 75 and 100 µM benznidazole induced an increasing of mitotic recombination events in diploid strain. Results were related to the induction of chromosomal breaks by the antiparasitic drug.
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书目信息
Memorias do Instituto Oswaldo Cruz
卷
100
期
3
页码
325
- 330
ISSN
0074-0276 | 1678-8060
出版者
Fundação Oswaldo Cruz (FIOCRUZ)
其它主题
Benznidazole; Somatic recombination; Homozigotization index
语言
英语
2024-12-11
DOAJ