Selection of Potential Therapeutic Bacteriophages that Lyse a CTX-M-15 Extended Spectrum β-Lactamase Producing Salmonella enterica Serovar Typhi Strain from the Democratic Republic of the Congo
2018
Elene Kakabadze | Khatuna Makalatia | Nino Grdzelishvili | Nata Bakuradze | Marina Goderdzishvili | Ia Kusradze | Marie-France Phoba | Octavie Lunguya | Cédric Lood | Rob Lavigne | Jan Jacobs | Stijn Deborggraeve | Tessa De Block | Sandra Van Puyvelde | David Lee | Aidan Coffey | Anahit Sedrakyan | Patrick Soentjens | Daniel De Vos | Jean-Paul Pirnay | Nina Chanishvili
Recently, a Salmonella Typhi isolate producing CTX-M-15 extended spectrum β-lactamase (ESBL) and with decreased ciprofloxacin susceptibility was isolated in the Democratic Republic of the Congo. We have selected bacteriophages that show strong lytic activity against this isolate and have potential for phage-based treatment of S. Typhi, and Salmonella in general.
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