Interference With Quorum-Sensing Signal Biosynthesis as a Promising Therapeutic Strategy Against Multidrug-Resistant Pathogens
2019
Osmel Fleitas Martínez | Osmel Fleitas Martínez | Pietra Orlandi Rigueiras | Állan da Silva Pires | William Farias Porto | William Farias Porto | William Farias Porto | Osmar Nascimento Silva | Cesar de la Fuente-Nunez | Cesar de la Fuente-Nunez | Cesar de la Fuente-Nunez | Cesar de la Fuente-Nunez | Cesar de la Fuente-Nunez | Octavio Luiz Franco | Octavio Luiz Franco | Octavio Luiz Franco
Faced with the global health threat of increasing resistance to antibiotics, researchers are exploring interventions that target bacterial virulence factors. Quorum sensing is a particularly attractive target because several bacterial virulence factors are controlled by this mechanism. Furthermore, attacking the quorum-sensing signaling network is less likely to select for resistant strains than using conventional antibiotics. Strategies that focus on the inhibition of quorum-sensing signal production are especially attractive because the enzymes involved are expressed in bacterial cells but are not present in their mammalian counterparts. We review here various approaches that are being taken to interfere with quorum-sensing signal production via the inhibition of autoinducer-2 synthesis, PQS synthesis, peptide autoinducer synthesis, and N-acyl-homoserine lactone synthesis. We expect these approaches will lead to the discovery of new quorum-sensing inhibitors that can help to stem the tide of antibiotic resistance.
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