Present in many cell types, non-degradative secretory autophagy is a newly discovered pathway in which autophagosomes fuse with the plasma membrane instead of lysosomes. Surprisingly, some viruses exploit secretory autophagy to exit cells non-lytically, shedding into the extracellular environment as particle populations contained within vesicles. As a result, this significantly enhances the infectivity of these viruses. In this paper, this novel cellular exit pathway is highlighted and its advantages for viral transmission discussed.
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书目信息
出版者
MDPI AG
其它主题
Picornavirus; Secretory autophagy; Quasispecies; Coxsackievirus; Syntaxin 17; Viral transmission
语言
英语
2024-12-11
2026-02-03
DOAJ